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Clay Travis’ College Football Predictions & Picks for Week 6

Clay Travis Oct 9, 2026 2:20 PM EDT3 min read

We’ve got a bunch of college football picks for you this week, including some big SEC matchups, the Red River Rivalry and several totals that I really like.

My Blood Bank Pick this week is the Over in the Georgia-Alabama game. I’m a bit apprehensive about the weather there, but I don’t think either offense is going to be restrained by the defenses based on what I have seen.

I also like Alabama -1.5 in the biggest game of the weekend in college football.

Clay’s Week 6 College Football Picks

  • Florida State at Louisville: Over 58.5
  • Texas A&M at Missouri: Missouri -3.5 and Over 48.5
  • Indiana at Nebraska: Nebraska +7.5
  • South Carolina at Florida: Florida -12.5 and Over 61.5
  • Texas vs. Oklahoma: Texas -8.5 and Under
  • UCLA at Oregon: Over 58.5
  • Ole Miss at Vanderbilt: Over 58.5
  • Tennessee at Arkansas: Arkansas +13.5 and Under 50.5
  • LSU at Kentucky: Kentucky +8.5
  • USC at Penn State: Under 54.5
  • Georgia at Alabama: Alabama -1.5 and Over 52.5 (Blood Bank Pick)

FSU-Louisville Over 58.5

Love this Florida State-Louisville Over. This is a game taking place on Friday night – do not miss that one.

Nebraska +7.5 vs. IU

I’ve been on Nebraska for big games for a long time. Indiana on the road at Nebraska, where I believe Big Noon is going to be with FOX.

Florida -12.5 and Over 61.5

I think Florida is going to bounce back from a poor performance against Missouri, cover and hit the Over.

Texas -8.5 vs. OU

I love the Under in this game. I think Texas is going to beat Oklahoma 20-6, so I’m on the Under as well in the neutral-site Red River Shootout.

Arkansas +13.5 and Under 50.5

I’ve got Arkansas plus the points and the Under in this game. I think Tennessee wins 12-7 in an all-time epic contest.

Odds subject to change.

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Clay Travis

Clay Travis

Clay Travis is an author, broadcaster, and media commentator best known as the founder of OutKick, the sports and culture site he built from scratch in 2011 and grew into one of the most influential digital platforms in sports media before it was folded into Fox News Digital fifteen years later. Born in 1979, Travis is a graduate of George Washington University and Vanderbilt University Law School, and worked as a lawyer before turning to sports media full-time. He now serves as a Fox News Media contributor and continues to host OutKick the Show with Clay Travis on FS1, in addition to co-hosting The Clay Travis and Buck Sexton Show. Known for a blend of sharp analysis, humor, and outspoken commentary on sports, politics, and culture, Travis has built a reputation as one of the most-heard voices in American media, reaching millions of listeners and readers across radio, television, and digital platforms. His writing and commentary range from college football to the business of sports to the intersection of sports and politics, and he's never shied away from a contrarian take.